Thomas Frank's men picked up a solid 2-1 win away at Crystal Palace last time out, after a difficult run of fixtures which saw them lose five of eight in all competitions, facing big-hitters Liverpool, Nottingham Forest, Arsenal and Newcastle. They will hope to recapture the home form which dazzled everyone during the opening months of the season.
Tottenham are as low as they have been in a very long time. Inspired by the enthusiasm of their youngsters, they beat Elfsborg in midweek to make it through to the Europa League last 16, but in the Premier League, it's been abysmal. Six league defeats in seven, and no win since they smashed whipping boys Southampton 5-0 in December, is plain and simple relegation form.
If they lose to Brentford this weekend, surely Ange Postecoglou's time will run out.
Brentford vs Tottenham Hotspur Team News
Thomas Frank delivered the rough news that Rico Henry, after returning from an extremely long injury spell, has suffered a fresh setback. He won't be available for this game, and nor will Gustavo Nunes, Aaron Hickey, Ethan Pinnock, Igor Thiago and Josh Dasilva.
Sympathy over Tottenham's long injury list is fast becoming criticism of Ange Postecoglou's training methods in some quarters, and his cause wasn't helped in midweek as centre-back Radu Dragusin came off with a knee issue. He will likely join the walking wounded of Wilson Odobert, Vicario, Dominic Solanke, Destiny Udogie, James Maddison, Brennan Johnson, Cristian Romero and Timo Werner - yes, the list is that long.
Brentford vs Tottenham Hotspur Possible Lineups
Despite coming off with knocks against Palace, Christian Nørgaard and Kevin Schade are expected to be fit and take part here. Frank should name an unchanged X1, assuming no late bids come in for Brian Mbeumo or Yoane Wissa, who is being heavily linked with this weekend's opponents Spurs.
Brentford Predicted Lineup (4-2-3-1): Flekken; Roerslev, Collins, van den Berg, Lewis-Potter; Nørgaard, Janelt; Mbeumo, Damsgaard, Schade; Wissa
Ange may see fit to give a chance to one or two of the youngsters who impressed so much in their midweek win over Elfsborg, and will once again have to revert to a makeshift backline as Dragusin heads back to the treatment room no sooner than he had left it.
Tottenham Hotspur Predicted Lineup (4-2-2-1): Kinsky; Porro, Gray, Van de Ven, Davies; Bentancur, Bissouma, Bergvall; Kulusevski, Scarlett, Son
Be sure to head back to Sporticos an hour before kick-off to get updated official lineups and other stats.
Brentford vs Tottenham Hotspur Prediction
No run this bad can go on forever. Spurs will surely turn the corner here. Brentford haven't been in sparkling form, but they should get some joy on the break against Postecoglou's reckless approach to shape, especially spurned on by their home fans. Nonetheless, in the end, with van de Ven probably getting back up to speed by now, Tottenham should be able to score more than they concede and get over the line.
Prediction: Brentford 2 - 3 Tottenham
Goals, goals and more goals is what can be expected from this one. Two forward-thinking coaches, and two sides with a penchant for leaving the back door firmly open. Anything fewer than three goals would be a huge shock - a game well worth a watch.
Fans in the UK can watch Brentford vs Tottenham on TV or via live stream with Sky Sports.