With the Ligue 1 title race all but over halfway through the season, and both of these teams keeping their eyes on their respective European playoff matches in midweek, it's difficult to see how this one will go.
PSG remain unbeaten in the French top flight this season and won 4-2 when these two met earlier in the season. They will be favourites but with the first leg of their UEFA Champions League playoff against Brest on the horizon, perhaps they will take their eye off the ball.
However, Monaco have the same conundrum. They face Benfica at home on Wednesday, and with any chance of catching PSG long gone, they will surely be looking ahead to that game.
Paris Saint-Germain vs Monaco Team News
Joao Neves and Warren Zaire-Emery are doubts for this one but could still make the squad if they prove their fitness.
Monaco are short on striking options as George Ilenikhena and Folarin Balogun are both injured. Meanwhile, on the defensive side, Wilfried Singo and Jordan Teze are also unavailable. Aleksandr Golovin came off at half-time of their last outing against Auxerre and is doubtful for this clash.
Paris Saint-Germain vs Monaco Possible Lineups
Luis Enrique allowed Randal Kolo Muani and then Milan Skriniar and Marco Asensio to all leave on loan deals during the January transfer window. They did bring in Kvicha Kvaratskhelia, but options are still limited in some areas. This means that whether he would prefer to rest them or not, all of the big hitters will likely play this game. Expect few, if any, changes from their last league win over Brest.
PSG Predicted Lineup (4-3-3): Donnarumma; Hakimi, Marquinhos, Pacho, Nuno Mendes; Lee Kang-In, Vitinha, Fabian Ruiz; Barcola, Dembele, Kvaratskhelia
Monaco will surely rotate somewhat and make sure they save the best they have for the game with Benfica in midweek.
Monaco Predicted Lineup (4-2-3-1): Macjecki; Vanderson, Teze, Salisu, Caio Henrique; Camara, Zakaria; Akliouche, Minamino, Ben Seghir; Embolo
Paris Saint-Germain vs Monaco Prediction
With both teams looking past this fixture, anything could happen, but ultimately the quality differential should prove enough to help PSG pick up the win.
Prediction: PSG 4 - 2 Monaco
With Ousmane Dembele hitting back-to-back league hat-tricks, and Monaco's Danish striker Mika Biereth scoring one of his own last time out, this game should provide plenty of entertainment for the neutral.
Fans in the UK can watch PSG vs Monaco via live streaming on the Ligue 1 pass.