1/16 finale
- 7 May
- San Jose Earthquakes2
- FC Sacramento Republic1
- 7 May
- Phoenix Rising FC1
- Houston Dynamo4
- 7 May
- Austin FC3
- El Paso Locomotive FC2
- 7 May
- Saint Louis City SC2
- Union Omaha SC0
- 7 May
- FC Dallas3
- Av Alta FC1
- 7 May
- Chicago Fire4
- Detroit City FC0
- 7 May
- Tampa Bay Rowdies0
- Orlando City SC5
- 7 May
- FC Louisville City0
- FC Minnesota United1
- 7 May
- Philadelphia Union1
- Indy Eleven1
- 7 May
- Rhode Island FC1
- New England Revolution2
- 7 May
- Pittsburgh Riverhounds1
- New York City FC0
- 6 May
- Tacoma Defiance2
- Portland Timbers3
- 6 May
- FC Colorado Springs Switchbacks1
- New York Red Bulls4
- 6 May
- Nashville SC1
- Chattanooga Red Wolves SC0
- 6 May
- DC United2
- Charleston Battery0
- 6 May
- North Carolina FC1
- Charlotte FC4